JAK-STAT-mediated chronic inflammation impairs cytotoxic T lymphocyte activation to decrease anti-PD-1 immunotherapy efficacy in pancreatic cancer

Human pancreatic cancer does not respond to immune check point blockade immunotherapy. One key feature of pancreatic cancer is the association between its progression and chronic inflammation. Emerging evidence supports a key role for the JAK-STAT pathway in pancreatic cancer inflammation. We aimed...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Lu, Chunwan, Talukder, Asif, Savage, Natasha M., Singh, Nagendra, Liu, Kebin
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5384417/
https://ncbi.nlm.nih.gov/pubmed/28405527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1291106
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