JAK-STAT-mediated chronic inflammation impairs cytotoxic T lymphocyte activation to decrease anti-PD-1 immunotherapy efficacy in pancreatic cancer

Human pancreatic cancer does not respond to immune check point blockade immunotherapy. One key feature of pancreatic cancer is the association between its progression and chronic inflammation. Emerging evidence supports a key role for the JAK-STAT pathway in pancreatic cancer inflammation. We aimed...

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Bibliografiska uppgifter
I publikationen:Oncoimmunology
Huvudupphovsmän: Lu, Chunwan, Talukder, Asif, Savage, Natasha M., Singh, Nagendra, Liu, Kebin
Materialtyp: Artigo
Språk:Inglês
Publicerad: Taylor & Francis 2017
Ämnen:
Original Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5384417/
https://ncbi.nlm.nih.gov/pubmed/28405527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1291106
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