Detection of prion seeding activity in the olfactory mucosa of patients with Fatal Familial Insomnia

Fatal Familial Insomnia (FFI) is a genetic prion disease caused by a point mutation in the prion protein gene (PRNP) characterized by prominent thalamic atrophy, diffuse astrogliosis and moderate deposition of PrP(Sc) in the brain. Here, for the first time, we demonstrate that the olfactory mucosa (...

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Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Redaelli, Veronica, Bistaffa, Edoardo, Zanusso, Gianluigi, Salzano, Giulia, Sacchetto, Luca, Rossi, Martina, De Luca, Chiara Maria Giulia, Di Bari, Michele, Portaleone, Sara Maria, Agrimi, Umberto, Legname, Giuseppe, Roiter, Ignazio, Forloni, Gianluigi, Tagliavini, Fabrizio, Moda, Fabio
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5384244/
https://ncbi.nlm.nih.gov/pubmed/28387370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46269
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