PMCA-generated prions from the olfactory mucosa of patients with Fatal Familial Insomnia cause prion disease in mice

BACKGROUND: Fatal Familial Insomnia (FFI) is a genetic prion disease caused by the D178N mutation in the prion protein gene (PRNP) in coupling phase with methionine at PRNP 129. In 2017, we have shown that the olfactory mucosa (OM) collected from FFI patients contained traces of PrPSc detectable by...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Bistaffa, Edoardo, Marín-Moreno, Alba, Espinosa, Juan Carlos, De Luca, Chiara Maria Giulia, Cazzaniga, Federico Angelo, Portaleone, Sara Maria, Celauro, Luigi, Legname, Giuseppe, Giaccone, Giorgio, Torres, Juan Maria, Moda, Fabio
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8064759/
https://ncbi.nlm.nih.gov/pubmed/33851575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.65311
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