Detection of prion seeding activity in the olfactory mucosa of patients with Fatal Familial Insomnia

Fatal Familial Insomnia (FFI) is a genetic prion disease caused by a point mutation in the prion protein gene (PRNP) characterized by prominent thalamic atrophy, diffuse astrogliosis and moderate deposition of PrP(Sc) in the brain. Here, for the first time, we demonstrate that the olfactory mucosa (...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Redaelli, Veronica, Bistaffa, Edoardo, Zanusso, Gianluigi, Salzano, Giulia, Sacchetto, Luca, Rossi, Martina, De Luca, Chiara Maria Giulia, Di Bari, Michele, Portaleone, Sara Maria, Agrimi, Umberto, Legname, Giuseppe, Roiter, Ignazio, Forloni, Gianluigi, Tagliavini, Fabrizio, Moda, Fabio
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2017
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5384244/
https://ncbi.nlm.nih.gov/pubmed/28387370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46269
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