Safe Recombinant Outer Membrane Vesicles that Display M2e Elicit Heterologous Influenza Protection

Recombinant, Escherichia coli-derived outer membrane vesicles (rOMVs), which display heterologous protein subunits, have potential as a vaccine adjuvant platform. One drawback to rOMVs is their lipopolysaccharide (LPS) content, limiting their translatability to the clinic due to potential adverse ef...

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Pubblicato in:Mol Ther
Autori principali: Watkins, Hannah C., Rappazzo, C. Garrett, Higgins, Jaclyn S., Sun, Xiangjie, Brock, Nicole, Chau, Annie, Misra, Aditya, Cannizzo, Joseph P.B., King, Michael R., Maines, Taronna R., Leifer, Cynthia A., Whittaker, Gary R., DeLisa, Matthew P., Putnam, David
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2017
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5383554/
https://ncbi.nlm.nih.gov/pubmed/28215994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.01.010
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