Immunization with outer membrane vesicles displaying conserved surface polysaccharide antigen elicits broadly antimicrobial antibodies

Many microbial pathogens produce a β-(1→6)–linked poly-N-acetyl-d-glucosamine (PNAG) surface capsule, including bacterial, fungal, and protozoan cells. Broadly protective immune responses to this single conserved polysaccharide antigen in animals are possible but only when a deacetylated poly-N-acet...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Stevenson, Taylor C., Cywes-Bentley, Colette, Moeller, Tyler D., Weyant, Kevin B., Putnam, David, Chang, Yung-Fu, Jones, Bradley D., Pier, Gerald B., DeLisa, Matthew P.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5889644/
https://ncbi.nlm.nih.gov/pubmed/29555731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718341115
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