Structural basis for antibody targeting of the broadly expressed microbial polysaccharide poly-N-acetylglucosamine

In response to the widespread emergence of antibiotic-resistant microbes, new therapeutic agents are required for many human pathogens. A non-mammalian polysaccharide, poly-N-acetyl-d-glucosamine (PNAG), is produced by bacteria, fungi, and protozoan parasites. Antibodies that bind to PNAG and its de...

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Vydáno v:J Biol Chem
Hlavní autoři: Soliman, Caroline, Walduck, Anna K., Yuriev, Elizabeth, Richards, Jack S., Cywes-Bentley, Colette, Pier, Gerald B., Ramsland, Paul A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Microbiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5892565/
https://ncbi.nlm.nih.gov/pubmed/29449370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001170
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