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Evasion of targeted cancer therapy through stem-cell-like reprogramming
Prostate cancer variants expressing alternative lineage markers appear at relapse from antiandrogen therapy. We show that loss of the retinoblastoma (RB1) and tumor protein 53 (TP53) genes drives expression of stem cell reprogramming factors, lineage plasticity, and antiandrogen resistance. Epigenet...
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| 出版年: | Mol Cell Oncol |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Taylor & Francis
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5383359/ https://ncbi.nlm.nih.gov/pubmed/28401192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2017.1291397 |
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