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Evasion of targeted cancer therapy through stem-cell-like reprogramming

Prostate cancer variants expressing alternative lineage markers appear at relapse from antiandrogen therapy. We show that loss of the retinoblastoma (RB1) and tumor protein 53 (TP53) genes drives expression of stem cell reprogramming factors, lineage plasticity, and antiandrogen resistance. Epigenet...

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發表在:Mol Cell Oncol
Main Authors: Wadosky, Kristine M., Ellis, Leigh, Goodrich, David W.
格式: Artigo
語言:Inglês
出版: Taylor & Francis 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5383359/
https://ncbi.nlm.nih.gov/pubmed/28401192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2017.1291397
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