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Dual inhibiting OCT4 and AKT potently suppresses the propagation of human cancer cells

AKT serves as an epigenetic modulator that links epigenetic regulation to cell survival and proliferation while the epigenetic mediator OCT4 critically controls stem cell pluripotency and self-renewal. Emerging evidence indicated their complicated interplays in cancer cells and cancer stem cells (CS...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Li, Wenxin, Zhou, Yanwen, Zhang, Xiaoqian, Yang, Ying, Dan, Songsong, Su, Tong, She, Shiqi, Dong, Weilai, Zhao, Qingwei, Jia, Jia, Yao, Hangping, Zheng, Min, Kang, Bo, Wang, Ying-Jie
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5382782/
https://ncbi.nlm.nih.gov/pubmed/28383051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46246
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