Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells

The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that responds to environmental toxicants, is increasingly recognized as a key player in embryogenesis and tumorigenesis. Here we show that a variety of tryptophan derivatives that act as endogenous AhR ligands can affect th...

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Publicat a:Nat Commun
Autors principals: Cheng, Jie, Li, Wenxin, Kang, Bo, Zhou, Yanwen, Song, Jiasheng, Dan, Songsong, Yang, Ying, Zhang, Xiaoqian, Li, Jingchao, Yin, Shengyong, Cao, Hongcui, Yao, Hangping, Zhu, Chenggang, Yi, Wen, Zhao, Qingwei, Xu, Xiaowei, Zheng, Min, Zheng, Shusen, Li, Lanjuan, Shen, Binghui, Wang, Ying-Jie
Format: Artigo
Idioma:Inglês
Publicat: Nature Pub. Group 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490363/
https://ncbi.nlm.nih.gov/pubmed/26059097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8209
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