Reciprocal regulation of Akt and Oct4 promotes the self-renewal and survival of embryonal carcinoma cells

Signaling via the Akt serine/threonine protein kinase plays critical roles in the self-renewal of embryonic stem cells and their malignant counterpart, embryonal carcinoma cells (ECCs). Here we show that in ECCs, Akt phosphorylated the master pluripotency factor Oct4 at threonine 235, and that the l...

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Main Authors: Lin, Yuanji, Yang, Ying, Li, Weihua, Chen, Qi, Li, Jie, Pan, Xiao, Zhou, Lina, Liu, Changwei, Chen, Chunsong, He, Jianqin, Cao, Hongcui, Yao, Hangping, Zheng, Li, Xu, Xiaowei, Xia, Zongping, Ren, Jiangtao, Xiao, Lei, Li, Lanjuan, Shen, Binghui, Zhou, Honglin, Wang, Ying-Jie
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3601782/
https://ncbi.nlm.nih.gov/pubmed/23041284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.08.030
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