LSD1-mediated demethylation of OCT4 safeguards pluripotent stem cells by maintaining the transcription of PORE-motif-containing genes

Reversible lysine methylation is essential for regulating histones and emerges to critically regulate non-histone proteins as well. Here we show that the master transcription factor OCT4 in pluripotent stem cells (PSCs) was methylated at multiple lysine residues. LSD1 that is highly expressed in PSC...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Dan, Songsong, Song, Yuelin, Duan, Xiaotao, Pan, Xiao, Chen, Cheng, She, Shiqi, Su, Tong, Li, Jingchao, Chen, Xinyu, Zhou, Yanwen, Chen, Wenjie, Zhang, Xiaobing, Pan, Xiaoyun, Wang, Ying-Jie, Kang, Bo
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8119428/
https://ncbi.nlm.nih.gov/pubmed/33986438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-89734-y
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