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ATR regulates OCT4 phosphorylation and safeguards human naïve pluripotency

Abstract Under specific conditions, cultured human embryonic stem cells (hESCs) corresponding to primed post-implantation epiblasts can be converted back to a ‘naïve pluripotency’ state that resembles the pre-implantation epiblasts. The core pluripotency factor OCT4 is known to be crucial in regulat...

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Kaydedildi:
Asıl Yazarlar: Xudong Ma, Cheng Chen, Xinyu Chen, Songsong Dan, Jianqiong Li, Xiaobing Zhang, Shiqi She, Jianwen Hu, Yan-Wen Zhou, Bo Kang, Ying-Jie Wang, Wenjie Chen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Portfolio 2025-05-01
Seri Bilgileri:Scientific Reports
Konular:
OCT4
ATR
Naïve pluripotency
Phosphoproteomics
Post-translational modification
Embryonic stem cells
Online Erişim:https://doi.org/10.1038/s41598-025-97829-z
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