KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines

KRAS is one of the most frequently mutated oncogenes in human cancer, yet remaining undruggable. To explore a new therapeutic strategy, a library of 5-methyl-indolo[3,2-c]quinoline derivatives (IQc) with a range of alkyldiamine side chains was designed to target DNA and RNA G-quadruplexes (G4) in th...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lavrado, João, Brito, Hugo, Borralho, Pedro M., Ohnmacht, Stephan A., Kim, Nam-Soon, Leitão, Clara, Pisco, Sílvia, Gunaratnam, Mekala, Rodrigues, Cecília M. P., Moreira, Rui, Neidle, Stephen, Paulo, Alexandra
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5382548/
https://ncbi.nlm.nih.gov/pubmed/25853628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09696
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