Analysis of origin and protein-protein interaction maps suggests distinct oncogenic role of nuclear EGFR during cancer evolution

Receptor tyrosine kinase EGFR usually is localized on plasma membrane to induce progression of many cancers including cancers in children (Bodey et al. In Vivo. 2005, 19:931-41), but it contains a nuclear localization signal (NLS) that mediates EGFR nuclear translocation (Lin et al. Nat Cell Biol. 2...

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Bibliographische Detailangaben
Veröffentlicht in:J Cancer
Hauptverfasser: Sharip, Ainur, Abdukhakimova, Diyora, Wang, Xiao, Kim, Alexey, Kim, Yevgeniy, Sharip, Aigul, Orakov, Askarbek, Miao, Lixia, Sun, Qinglei, Chen, Yue, Chen, Zhenbang, Xie, Yingqiu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5381180/
https://ncbi.nlm.nih.gov/pubmed/28382154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.17961
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