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An ectopic CTCF binding element inhibits Tcrd rearrangement by limiting contact between Vδ and Dδ gene segments(,2)

Chromatin looping mediated by the CCCTC binding factor (CTCF) regulates V(D)J recombination at antigen receptor loci. CTCF-mediated looping can influence recombination signal sequence (RSS) accessibility by regulating enhancer activation of germline promoters. CTCF-mediated looping has also been sho...

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Détails bibliographiques
Publié dans:J Immunol
Auteurs principaux: Chen, Liang, Zhao, Lijuan, Alt, Frederick W., Krangel, Michael S.
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380924/
https://ncbi.nlm.nih.gov/pubmed/27613698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1601124
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