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A discrete chromatin loop in the murine Tcra-Tcrd locus shapes the TCRδ and TCRα repertoires

The Tcra-Tcrd locus undergoes V(D)J recombination in CD4(−)CD8(−)double-negative thymocytes and CD4(+)CD8(+) double-positive thymocytes to generate diverse TCRδ and TCRα repertoires, respectively. Here we reveal a Tcra-Tcrd locus chromatin interaction network in double-negative thymocytes that was f...

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Bibliografiske detaljer
Udgivet i:Nat Immunol
Main Authors: Chen, Liang, Carico, Zachary, Shih, Han-Yu, Krangel, Michael S.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4575630/
https://ncbi.nlm.nih.gov/pubmed/26258942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3232
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