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Regulation of TCR δ and α repertoires by local and long-distance control of variable gene segment chromatin structure

Murine Tcrd and Tcra gene segments reside in a single genetic locus and undergo recombination in CD4(−)CD8(−) (double negative [DN]) and CD4(+)CD8(+) (double positive [DP]) thymocytes, respectively. TcraTcrd locus variable gene segments are subject to complex regulation. Only a small subset of ∼100...

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Bibliografski detalji
Glavni autori: Hawwari, Abbas, Krangel, Michael S.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2005
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212846/
https://ncbi.nlm.nih.gov/pubmed/16087716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050680
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