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An ectopic CTCF binding element inhibits Tcrd rearrangement by limiting contact between Vδ and Dδ gene segments(,2)

Chromatin looping mediated by the CCCTC binding factor (CTCF) regulates V(D)J recombination at antigen receptor loci. CTCF-mediated looping can influence recombination signal sequence (RSS) accessibility by regulating enhancer activation of germline promoters. CTCF-mediated looping has also been sho...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Chen, Liang, Zhao, Lijuan, Alt, Frederick W., Krangel, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380924/
https://ncbi.nlm.nih.gov/pubmed/27613698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1601124
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