Topoisomerase II Inhibitors Induce DNA Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion

Ebola virus (EBOV) protein VP35 inhibits production of interferon alpha/beta (IFN) by blocking RIG-I-like receptor signaling pathways, thereby promoting virus replication and pathogenesis. A high-throughput screening assay, developed to identify compounds that either inhibit or bypass VP35 IFN-antag...

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Veröffentlicht in:mBio
Hauptverfasser: Luthra, Priya, Aguirre, Sebastian, Yen, Benjamin C., Pietzsch, Colette A., Sanchez-Aparicio, Maria T., Tigabu, Bersabeh, Morlock, Lorraine K., García-Sastre, Adolfo, Leung, Daisy W., Williams, Noelle S., Fernandez-Sesma, Ana, Bukreyev, Alexander, Basler, Christopher F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380843/
https://ncbi.nlm.nih.gov/pubmed/28377530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00368-17
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