Pilot Phase II Trial of Imatinib Mesylate in Neurofibromatosis Type 1 patients with Plexiform Neurofibromas

BACKGROUND: Plexiform neurofibromas (PN) are slow growing chemoradiotherapy resistant tumours arising in patients with neurofibromatosis type I (NF1). Currently there are no viable therapeutic options for patients whose life-threatening plexiform neurofibromas cannot be surgically removed due to pro...

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Gepubliceerd in:Lancet Oncol
Hoofdauteurs: Robertson, Kent A., Nalepa, Grzegorz, Yang, Feng-Chun, Bowers, Daniel C., Ho, Chang Y., Hutchins, Gary D., Croop, James M., Vik, Terry A., Denne, Scott C., Parada, Luis F., Hingtgen, Cynthia M., Walsh, Laurence E., Yu, Menggang, Pradhan, Kamnesh R., Edwards-Brown, Mary K., Cohen, Mervyn D., Fletcher, James W., Travers, Jeffrey B., Staser, Karl W., Lee, Melissa W., Sherman, Marcie R., Davis, Cynthia J., Miller, Lucy C., Ingram, David A., Clapp, D. Wade
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380388/
https://ncbi.nlm.nih.gov/pubmed/23099009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1470-2045(12)70414-X
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