Pilot Phase II Trial of Imatinib Mesylate in Neurofibromatosis Type 1 patients with Plexiform Neurofibromas

BACKGROUND: Plexiform neurofibromas (PN) are slow growing chemoradiotherapy resistant tumours arising in patients with neurofibromatosis type I (NF1). Currently there are no viable therapeutic options for patients whose life-threatening plexiform neurofibromas cannot be surgically removed due to pro...

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Detalhes bibliográficos
Publicado no:Lancet Oncol
Main Authors: Robertson, Kent A., Nalepa, Grzegorz, Yang, Feng-Chun, Bowers, Daniel C., Ho, Chang Y., Hutchins, Gary D., Croop, James M., Vik, Terry A., Denne, Scott C., Parada, Luis F., Hingtgen, Cynthia M., Walsh, Laurence E., Yu, Menggang, Pradhan, Kamnesh R., Edwards-Brown, Mary K., Cohen, Mervyn D., Fletcher, James W., Travers, Jeffrey B., Staser, Karl W., Lee, Melissa W., Sherman, Marcie R., Davis, Cynthia J., Miller, Lucy C., Ingram, David A., Clapp, D. Wade
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380388/
https://ncbi.nlm.nih.gov/pubmed/23099009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1470-2045(12)70414-X
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