Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity

The phagocyte respiratory burst is crucial for innate immunity. The transfer of electrons to oxygen is mediated by a membrane-bound heterodimer, comprising gp91phox and p22phox subunits. Deficiency of either subunit leads to severe immunodeficiency. We describe Eros (essential for reactive oxygen sp...

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Veröffentlicht in:J Exp Med
Hauptverfasser: Thomas, David C., Clare, Simon, Sowerby, John M., Pardo, Mercedes, Juss, Jatinder K., Goulding, David A., van der Weyden, Louise, Storisteanu, Daniel, Prakash, Ananth, Espéli, Marion, Flint, Shaun, Lee, James C., Hoenderdos, Kim, Kane, Leanne, Harcourt, Katherine, Mukhopadhyay, Subhankar, Umrania, Yagnesh, Antrobus, Robin, Nathan, James A., Adams, David J., Bateman, Alex, Choudhary, Jyoti S., Lyons, Paul A., Condliffe, Alison M., Chilvers, Edwin R., Dougan, Gordon, Smith, Kenneth G.C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2017
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5379978/
https://ncbi.nlm.nih.gov/pubmed/28351984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161382
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