Hypoxia upregulates neutrophil degranulation and potential for tissue injury

BACKGROUND: The inflamed bronchial mucosal surface is a profoundly hypoxic environment. Neutrophilic airway inflammation and neutrophil-derived proteases have been linked to disease progression in conditions such as COPD and cystic fibrosis, but the effects of hypoxia on potentially harmful neutroph...

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Detalhes bibliográficos
Publicado no:Thorax
Main Authors: Hoenderdos, Kim, Lodge, Katharine M, Hirst, Robert A, Chen, Cheng, Palazzo, Stefano G C, Emerenciana, Annette, Summers, Charlotte, Angyal, Adri, Porter, Linsey, Juss, Jatinder K, O'Callaghan, Christopher, Chilvers, Edwin R, Condliffe, Alison M
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2016
Assuntos:
Respiratory Infection
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5099189/
https://ncbi.nlm.nih.gov/pubmed/27581620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2015-207604
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