Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5

Sensing of viral RNA by the cytosolic receptors RIG-I and melanoma differentiation-associated gene 5 (MDA5) leads to innate antiviral response. How RIG-I and MDA5 are dynamically regulated in innate antiviral response is not well understood. Here, we show that TRIM38 positively regulates MDA5- and R...

Full description

Saved in:
Bibliographic Details
Published in:J Exp Med
Main Authors: Hu, Ming-Ming, Liao, Chen-Yang, Yang, Qing, Xie, Xue-Qin, Shu, Hong-Bing
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2017
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5379974/
https://ncbi.nlm.nih.gov/pubmed/28250012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161015
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items