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Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5
Sensing of viral RNA by the cytosolic receptors RIG-I and melanoma differentiation-associated gene 5 (MDA5) leads to innate antiviral response. How RIG-I and MDA5 are dynamically regulated in innate antiviral response is not well understood. Here, we show that TRIM38 positively regulates MDA5- and R...
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| Pubblicato in: | J Exp Med |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5379974/ https://ncbi.nlm.nih.gov/pubmed/28250012 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161015 |
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