Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase

Viral infection leads to activation of the transcription factors interferon regulatory factor-3 and NF-κB, which collaborate to induce type I IFNs. The RNA helicase proteins RIG-I and MDA5 were recently identified as two cytoplasmic viral RNA sensors that recognize different species of viral RNAs pr...

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Bibliographische Detailangaben
Hauptverfasser: Diao, Feici, Li, Shu, Tian, Yang, Zhang, Min, Xu, Liang-Guo, Zhang, Yan, Wang, Rui-Peng, Chen, Danying, Zhai, Zhonghe, Zhong, Bo, Tien, Po, Shu, Hong-Bing
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2007
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1913852/
https://ncbi.nlm.nih.gov/pubmed/17600090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700544104
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