Epithelial Fli1 deficiency drives systemic autoimmunity and fibrosis: Possible roles in scleroderma

Systemic sclerosis (SSc), or scleroderma, is a multisystem autoimmune disorder characterized by vasculopathy and fibrosis in the skin and internal organs, most frequently in the esophagus and lungs. Hitherto, studies on SSc pathogenesis centered on immune cells, vascular cells, and fibroblasts. Alth...

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Bibliographic Details
Published in:J Exp Med
Main Authors: Takahashi, Takehiro, Asano, Yoshihide, Sugawara, Koji, Yamashita, Takashi, Nakamura, Kouki, Saigusa, Ryosuke, Ichimura, Yohei, Toyama, Tetsuo, Taniguchi, Takashi, Akamata, Kaname, Noda, Shinji, Yoshizaki, Ayumi, Tsuruta, Daisuke, Trojanowska, Maria, Sato, Shinichi
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2017
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5379967/
https://ncbi.nlm.nih.gov/pubmed/28232470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160247
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