Altered properties of endothelial cells and mesenchymal stem cells underlying the development of scleroderma-like vasculopathy in Klf5(+/−);Fli1(+/−) mice

OBJECTIVE: We previously established a new animal model (Klf5(+/−);Fli1(+/−) mice) broadly recapitulating fundamental pathologic features of systemic sclerosis (SSc). SSc vasculopathy is believed to occur as a result of impaired vascular remodeling, but its detailed mechanism has remained unknown. T...

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Veröffentlicht in:Arthritis Rheumatol
Hauptverfasser: Nakamura, Kouki, Taniguchi, Takashi, Hirabayashi, Megumi, Yamashita, Takashi, Saigusa, Ryosuke, Miura, Shunsuke, Takahashi, Takehiro, Toyama, Tetsuo, Ichimura, Yohei, Yoshizaki, Ayumi, Trojanowska, Maria, Fujiu, Katsuhito, Nagai, Ryozo, Sato, Shinichi, Asano, Yoshihide
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7722222/
https://ncbi.nlm.nih.gov/pubmed/32627966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.41423
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