ILC2 Suppression by Regulatory T Cells Attenuates Airway Hyperreactivity and Requires ICOS:ICOS-Ligand Interaction

BACKGROUND: Atopic diseases including asthma exacerbate type 2 immune responses and involve a number of immune cell types, including regulatory T cells (Tregs) and the emerging group 2 innate lymphoid cells (ILC2s). While ILC2s are potent producers of type 2 cytokines, the regulation of ILC2 activat...

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Veröffentlicht in:J Allergy Clin Immunol
Hauptverfasser: Rigas, Diamanda, Lewis, Gavin, Aron, Jennifer L., Wang, Bowen, Banie, Homayon, Sankaranarayanan, Ishwarya, Galle-Treger, Lauriane, Maazi, Hadi, Lo, Richard, Freeman, Gordon J., Sharpe, Arlene H., Soroosh, Pejman, Akbari, Omid
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378695/
https://ncbi.nlm.nih.gov/pubmed/27717665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2016.08.034
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