PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity

Allergic asthma is a leading chronic disease associated with airway hyperreactivity (AHR). Type-2 innate lymphoid cells (ILC2s) are a potent source of T-helper 2 (Th2) cytokines that promote AHR and lung inflammation. As the programmed cell death protein-1 (PD-1) inhibitory axis regulates a variety...

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Publicado no:Nat Commun
Principais autores: Helou, Doumet Georges, Shafiei-Jahani, Pedram, Lo, Richard, Howard, Emily, Hurrell, Benjamin P., Galle-Treger, Lauriane, Painter, Jacob D., Lewis, Gavin, Soroosh, Pejman, Sharpe, Arlene H., Akbari, Omid
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7417739/
https://ncbi.nlm.nih.gov/pubmed/32778730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17813-1
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