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Distal CpG islands can serve as alternative promoters to transcribe genes with silenced proximal promoters
DNA methylation at the promoter of a gene is presumed to render it silent, yet a sizable fraction of genes with methylated proximal promoters exhibit elevated expression. Here, we show, through extensive analysis of the methylome and transcriptome in 34 tissues, that in many such cases, transcriptio...
Enregistré dans:
| Publié dans: | Genome Res |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Cold Spring Harbor Laboratory Press
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5378174/ https://ncbi.nlm.nih.gov/pubmed/28223400 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.212050.116 |
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