Reporter Gene Silencing in Targeted Mouse Mutants Is Associated with Promoter CpG Island Methylation

Targeted mutations in mouse disrupt local chromatin structure and may lead to unanticipated local effects. We evaluated targeted gene promoter silencing in a group of six mutants carrying the tm1a Knockout Mouse Project allele containing both a LacZ reporter gene driven by the native promoter and a...

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Bibliographic Details
Published in:PLoS One
Main Authors: Kirov, Julia V., Adkisson, Michael, Nava, A. J., Cipollone, Andreana, Willis, Brandon, Engelhard, Eric K., Lloyd, K. C. Kent, de Jong, Pieter, West, David B.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537176/
https://ncbi.nlm.nih.gov/pubmed/26275310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134155
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