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Reporter Gene Silencing in Targeted Mouse Mutants Is Associated with Promoter CpG Island Methylation
Targeted mutations in mouse disrupt local chromatin structure and may lead to unanticipated local effects. We evaluated targeted gene promoter silencing in a group of six mutants carrying the tm1a Knockout Mouse Project allele containing both a LacZ reporter gene driven by the native promoter and a...
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| Published in: | PLoS One |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Public Library of Science
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4537176/ https://ncbi.nlm.nih.gov/pubmed/26275310 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134155 |
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