Reporter Gene Silencing in Targeted Mouse Mutants Is Associated with Promoter CpG Island Methylation

Targeted mutations in mouse disrupt local chromatin structure and may lead to unanticipated local effects. We evaluated targeted gene promoter silencing in a group of six mutants carrying the tm1a Knockout Mouse Project allele containing both a LacZ reporter gene driven by the native promoter and a...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kirov, Julia V., Adkisson, Michael, Nava, A. J., Cipollone, Andreana, Willis, Brandon, Engelhard, Eric K., Lloyd, K. C. Kent, de Jong, Pieter, West, David B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537176/
https://ncbi.nlm.nih.gov/pubmed/26275310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134155
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