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A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype
Approximately 70% of KRAS-positive colorectal cancers (CRCs) have a CpG island methylator phenotype (CIMP) characterized by aberrant DNA hypermethylation and transcriptional silencing of many genes. The factors involved in, and the mechanistic basis of, CIMP is not understood. Among the CIMP genes a...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3949416/ https://ncbi.nlm.nih.gov/pubmed/24623306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02313 |
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