Cargando...
The BRAF Oncoprotein Functions Through the Transcriptional Repressor MAFG to Mediate the CpG Island Methylator Phenotype
Most colorectal cancers (CRCs) containing activated BRAF (BRAF[V600E]) have a CpG island methylator phenotype (CIMP) characterized by aberrant hypermethylation of many genes, including the mismatch repair gene MLH1. MLH1 silencing results in microsatellite instability and a hypermutable phenotype. T...
Gardado en:
| Main Authors: | , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
|
| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4170521/ https://ncbi.nlm.nih.gov/pubmed/25219500 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.08.010 |
| Tags: |
Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!
|