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The BRAF Oncoprotein Functions Through the Transcriptional Repressor MAFG to Mediate the CpG Island Methylator Phenotype
Most colorectal cancers (CRCs) containing activated BRAF (BRAF[V600E]) have a CpG island methylator phenotype (CIMP) characterized by aberrant hypermethylation of many genes, including the mismatch repair gene MLH1. MLH1 silencing results in microsatellite instability and a hypermutable phenotype. T...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4170521/ https://ncbi.nlm.nih.gov/pubmed/25219500 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.08.010 |
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