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CpG island methylation affects accessibility of the proximal BRCA1 promoter to transcription factors
To understand the mechanism of transcriptional down-regulation of BRCA1 by promoter methylation, we screened 51 breast cancer cell lines and identified HCC38 as another BRCA1 promoter-methylated cell line in addition to UACC3199. There was low expression of BRCA1 mRNA and BRCA1 protein in both cell...
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| Publicat a: | Breast Cancer Res Treat |
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| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6697119/ https://ncbi.nlm.nih.gov/pubmed/19466541 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-009-0422-1 |
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