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Orphan CpG islands as alternative promoters

CpG islands (CGIs) are associated with ∼60% of mammalian promoters. Most unmethylated CGIs exhibit transcriptional activity, which has led to their co-option as promoters by retrogenes. CGIs may also serve as alternative promoters for downstream genes with methylated promoters, with implications on...

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Publicado en:Transcription
Autores principales: Sarda, Shrutii, Hannenhalli, Sridhar
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927659/
https://ncbi.nlm.nih.gov/pubmed/29099304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541264.2017.1373209
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