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Frequent hypermethylation of orphan CpG islands with enhancer activity in cancer
BACKGROUND: CpG islands (CGIs) are interspersed DNA sequences that have unusually high CpG ratios and GC contents. CGIs are typically located in the promoter of protein-coding genes. They normally lack DNA methylation but become hypermethylated and induce repression of associated genes in cancer. Ho...
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| Publicado no: | BMC Med Genomics |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4989897/ https://ncbi.nlm.nih.gov/pubmed/27534853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-016-0198-1 |
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