Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells

Reversing DNA methylation abnormalities and associated gene silencing, through inhibiting DNA methyltransferases (DNMTs) is an important potential cancer therapy paradigm. Maximizing this potential requires defining precisely how these enzymes maintain genome-wide, cancer-specific DNA methylation. T...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Genome Res
Egile Nagusiak: Cai, Yi, Tsai, Hsing-Chen, Yen, Ray-Whay Chiu, Zhang, Yang W., Kong, Xiangqian, Wang, Wei, Xia, Limin, Baylin, Stephen B.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cold Spring Harbor Laboratory Press 2017
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378172/
https://ncbi.nlm.nih.gov/pubmed/28232479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.208108.116
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