Using a biologically annotated library to analyze the anticancer mechanism of serine palmitoyl transferase (SPT) inhibitors

Mechanistic understanding is crucial to anticancer drug discovery. Here, we reveal that inhibition of serine palmitoyl transferase (SPT), the rate‐limiting enzyme in sphingolipid synthesis, induced death in a lung cancer cell line via a necrosis‐dependent pathway. To elucidate the mechanism of cell...

Full description

Saved in:
Bibliographic Details
Published in:FEBS Open Bio
Main Authors: Sano, Osamu, Kazetani, Ken‐ichi, Adachi, Ryutaro, Kurasawa, Osamu, Kawamoto, Tomohiro, Iwata, Hidehisa
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5377399/
https://ncbi.nlm.nih.gov/pubmed/28396835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12196
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items