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Role of malate dehydrogenase in facilitating lactate dehydrogenase to support the glycolysis pathway in tumors
High aerobic glycolysis, as one of the hallmarks of cancer cells, requires nicotinamide adenine dinucleotide (NAD(+)) as a vital co-factor, to guarantee the flow of glycolysis. Malate dehydrogenase (MDH), as an important enzyme in cancer metabolism, is a source of NAD(+) additional to lactate dehydr...
Gespeichert in:
| Veröffentlicht in: | Biomed Rep |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
D.A. Spandidos
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5374908/ https://ncbi.nlm.nih.gov/pubmed/28413646 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/br.2017.873 |
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