Identification of Novel Class of Triazolo-Thiadiazoles as Potent Inhibitors of Human Heparanase and their Anticancer Activity

BACKGROUND: Expression and activity of heparanase, an endoglycosidase that cleaves heparan sulfate (HS) side chains of proteoglycans, is associated with progression and poor prognosis of many cancers which makes it an attractive drug target in cancer therapeutics. METHODS: In the present work, we re...

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Vydáno v:BMC Cancer
Hlavní autoři: Baburajeev, C. P., Mohan, Chakrabhavi Dhananjaya, Rangappa, Shobith, Mason, Daniel J., Fuchs, Julian E., Bender, Andreas, Barash, Uri, Vlodavsky, Israel, Basappa, Rangappa, Kanchugarakoppal S.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5374561/
https://ncbi.nlm.nih.gov/pubmed/28359266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3214-8
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