Identification of Novel Class of Triazolo-Thiadiazoles as Potent Inhibitors of Human Heparanase and their Anticancer Activity

BACKGROUND: Expression and activity of heparanase, an endoglycosidase that cleaves heparan sulfate (HS) side chains of proteoglycans, is associated with progression and poor prognosis of many cancers which makes it an attractive drug target in cancer therapeutics. METHODS: In the present work, we re...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:BMC Cancer
Egile Nagusiak: Baburajeev, C. P., Mohan, Chakrabhavi Dhananjaya, Rangappa, Shobith, Mason, Daniel J., Fuchs, Julian E., Bender, Andreas, Barash, Uri, Vlodavsky, Israel, Basappa, Rangappa, Kanchugarakoppal S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2017
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5374561/
https://ncbi.nlm.nih.gov/pubmed/28359266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3214-8
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