Targeting Heparanase in Cancer: Inhibition by Synthetic, Chemically Modified, and Natural Compounds

Heparanase is an endoglycosidase involved in remodeling the extracellular matrix and thereby in regulating multiple cellular processes and biological activities. It cleaves heparan sulfate (HS) side chains of HS proteoglycans into smaller fragments and hence regulates tissue morphogenesis, different...

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Detalhes bibliográficos
Publicado no:iScience
Main Authors: Mohan, Chakrabhavi Dhananjaya, Hari, Swetha, Preetham, Habbanakuppe D., Rangappa, Shobith, Barash, Uri, Ilan, Neta, Nayak, S. Chandra, Gupta, Vijai K., Basappa, Vlodavsky, Israel, Rangappa, Kanchugarakoppal S.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548846/
https://ncbi.nlm.nih.gov/pubmed/31103854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.04.034
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