Identification of Novel Class of Triazolo-Thiadiazoles as Potent Inhibitors of Human Heparanase and their Anticancer Activity

BACKGROUND: Expression and activity of heparanase, an endoglycosidase that cleaves heparan sulfate (HS) side chains of proteoglycans, is associated with progression and poor prognosis of many cancers which makes it an attractive drug target in cancer therapeutics. METHODS: In the present work, we re...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Baburajeev, C. P., Mohan, Chakrabhavi Dhananjaya, Rangappa, Shobith, Mason, Daniel J., Fuchs, Julian E., Bender, Andreas, Barash, Uri, Vlodavsky, Israel, Basappa, Rangappa, Kanchugarakoppal S.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5374561/
https://ncbi.nlm.nih.gov/pubmed/28359266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3214-8
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