Efficacy of ALK5 inhibition in myelofibrosis

Myelofibrosis (MF) is a bone marrow disorder characterized by clonal myeloproliferation, aberrant cytokine production, extramedullary hematopoiesis, and bone marrow fibrosis. Although somatic mutations in JAK2, MPL, and CALR have been identified in the pathogenesis of these diseases, inhibitors of t...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Yue, Lanzhu, Bartenstein, Matthias, Zhao, Wanke, Ho, Wanting Tina, Han, Ying, Murdun, Cem, Mailloux, Adam W., Zhang, Ling, Wang, Xuefeng, Budhathoki, Anjali, Pradhan, Kith, Rapaport, Franck, Wang, Huaquan, Shao, Zonghong, Ren, Xiubao, Steidl, Ulrich, Levine, Ross L., Zhao, Zhizhuang Joe, Verma, Amit, Epling-Burnette, Pearlie K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5374075/
https://ncbi.nlm.nih.gov/pubmed/28405618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.90932
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